研究業績

《英文論文》
1. Akihiro Kondo, Md. Golam Mostofa, Katsuya Miyake, Mashu Terasawa, Nafisa Islam, Akter MST Yeasmin, Talukdar Muhammad Waliullah, Tomotake Kanki, and Takashi Ushimaru* (2018) Cdc14 phosphatase promotes TORC1-regulated autophagy in yeast. J Mol Cell (in press)
2. Muhammad Arifur Rahman, Md. Golam Mostofa, and Takashi Ushimaru* (2018) The Nem1/Spo7–Pah1/lipin axis is required for autophagy induction after TORC1 inactivation. FEBS J 2018 Mar 31. doi: 10.1111/febs.14448. [Epub ahead of print]
3. Naoki Koike, Yuuki Hatano and Takashi Ushimaru* (2018) Heat shock transcriptional factor mediates mitochondrial unfolded protein response. Curr Gent 2018 Feb 8. doi: 10.1007/s00294-018-0809-9. PMID:29423676
4. Talukdar Muhammad Waliullah, Akter MST Yeasmin, Atsuki Kaneko, Naoki Koike, Mashu Terasawa, Takaya Totsuka and Takashi Ushimaru* (2017) Rim15 and Sch9 kinases are involved in induction of autophagic degradation of ribosomes in budding yeast. Biosci Biotechnol Biochem. 2017 Feb;81(2):307-310. doi: 10.1080/09168451.2016.1234928. PMID: 27659307, 2016 Sep 23:1-4. [Epub ahead of print]
5. Akter MST Yeasmin, Talukdar Muhammad Waliullah, Akihiro Kondo, Atsuki Kaneko, Naoki Koike and Takashi Ushimaru* (2016) Orchestrated action of PP2A antagonizes Atg13 phosphorylation and promotes autophagy after the inactivation of TORC1. PLOS ONE. 2016 Dec 14;11(12):e0166636. doi: 10.1371/journal.pone.0166636. PMID: 27973551
6. Yuhki Hatano, Naoki Koike, Asuka Suzuki, and Takashi Ushimaru* (2016) Positive feedback promotes mitotic exit via the APC/C-Cdh1-separase-Cdc14 axis in budding yeast. Cell Signal. 2016 Jul 11;28(10):1545-1554. doi: 10.1016/j.cellsig.2016.07.005. PMID: 27418100
7. Yoshihito Shimizu, Masayoshi Nagai, Akter MST Yeasmin, Naoki Koike, Muhammad Waliullah Talukdar and Takashi Ushimaru* (2016) Elucidation of novel budding yeast separase mutants. Biosci Biotechnol Biochem. 2016 Mar 80(3):473-478. doi: 10.1080/09168451.2015.1101337. Epub 2015 Nov 2. PMID: 26523765
8. Yeasmin AM, Waliullah TM, Kondo A, Ushimaru T*. (2015) Yvh1 protein phosphatase is required for pre-autophagosomal structure formation after TORC1 inactivation. Biosci Biotechnol Biochem. (2015) 2015 June; 79(12):2022-5 PMID: 26125457.
9. Kentaro Maegawa, Rumi Takii, Takashi, Ushimaru and Akiko Kozaki (2015) Evolutionary conservation of TORC1 components, TOR, Raptor, and LST8, between rice and yeast. Mol Genet Genomics. 2015 Oct; 290(5):2019-30 PMID: 25956502
10. Tainaka, K.-I., Ushimaru, T., Hagiwara, T., Yoshimura, (2014) Lattice gas model for budding yeast: A new approach for density effects J.
 Procedia Computer Science
 29:270-280.
11. Masayoshi Nagai, and Takashi Ushimaru* (2014) Cdh1 is an antagonist of the spindle assembly checkpoint. Cell Signal 2014 Oct; 26(10):2217-2222. doi: 10.1016/j.cellsig.2014.07.007.
12. Shigeru Nakaya, Hajime Kobori, Atsushi Sekiya, Hirokazu Kawagishi, and Takashi Ushimaru* (2014) Anti-aging and anti-microbial effects of melleolide on different types of yeast. Biosci. Biotechnol. Biochem. 2014 Mar;78(3):455-457.
13. Shigeru Nakaya, Saki Mizuno, Hiroki Ishigami, Yasuhiro Yamakawa, Hirokazu Kawagishi and Takashi Ushimaru* (2012) A new rapid screening system for anti-aging compounds using budding yeast and identification of beauveriolide I as a potent active compound. Biosci. Biotechnol. Biochem. 76(6):1226-1228
14. Kazuhiro Toda, Kayoko Naito, Satoru Mase, Masaru Ueno, Masahiro Uritani, Ayumu Yamamoto and Takashi Ushimaru* (2012) APC/C-Cdh1-dependent anaphase and telophase progression during mitotic slippage. Cell Div. 7(1):4 (9 February 2012)
15. Toshiyuki Hagiwara, Takashi Ushimaru, Kei-ichi Tainaka, Hironori Kurachi and Jin Yoshimura (2011) Apoptosis at Inflection Point in Liquid Culture of Budding Yeasts. PLoS One 6 (4) e19224 (1-7).
16. Katsue Daicho, Nishiho Makino, Toshiki Hiraki, Masaru Ueno, Masahiro Uritani, Fumiyoshi Abe, and Takashi Ushimaru* (2009) Sorting defects of the tryptophan permease Tat2 in an erg2 yeast mutant. FEMS Microbiol Lett. 298(2):218-27.
17. Maria C. Rubio, Manuel Becana, Sumio Kanematsu, Takashi Ushimaru and Euan K. James (2009) Immunolocalization of antioxidant enzymes in high-pressure frozen root and stem nodules of Sesbania rostrata. New Phytol. 183(2):395-407.
18. Aktar Uzzaman Chouduri, Toshinobu Tokumoto, Hideo Dohra, Takashi Ushimaru and Shinpei Yamada (2008) Functional and biochemical characterization of the 20S proteasome in a yeast temperature-sensitive mutant, rpt6-1. BMC Biochem. Jul 21;9(1):20.
19. Katsue Daicho, Hironori Maruyama, Asuka Suzuki, Masaru Ueno, Masahiro Uritani and Takashi Ushimaru* (2007) The ergosterol biosynthesis inhibitor zaragozic acid promotes vacuolar degradation of the tryptophan permease Tat2p in yeast. Biochim Biophys Acta.- Biomembranes 2007 Jul;1768(7):1681-1690.
20. Masahiro Uritani, Hidetoshi Hidaka, Yukari Hotta, Masaru Ueno, Takashi Ushimaru and Takashi Toda (2006) Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase. Genes Cell 2006 Dec;11(12):1367-1379.
21. Takashi Ushimaru*, Tomofumi Nakagawa, Yuko Fujioka, Katsue Daicho, Makiko Naito, Yuzo Yamauchi, Hideko Nonaka, Katsumi Amako, Kazuki Yamawaki and Norio Murata (2006) Transgenic Arabidopsis plants expressing the rice dehydroascorbate reductase gene are resistant to salt stress. J. Plant Physiol. Nov 1; 163(11): 1179-1184.
22. Yoshimi Honma, Aiko Kitamura, Ryo Shioda, Hironori Maruyama, Kanako Ozaki, Yoko Oda, Thierry Mini, Paul Jenö, Yasushi Maki, Kazuhito Yonezawa, Ed Hurt, Masaru Ueno, Masahiro Uritani, Michael N. Hall, and Takashi Ushimaru* (2006) TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients. EMBO J. 2006 Aug 23;25(16):3832-3842
23. Kei-ichi Tainaka, Jin Yoshimura, and Takashi Ushimaru (2006) Stage-Dependent Density Effect in the Cell Cycle of Budding Yeast. J. Theor. Biol. 2006 Oct 7;242(3):736-742
24. Katsumi Amako, Takashi Ushimaru, Ayami Ishikawa, Chiaki Iwamoto, Yasuka Ogishi, Ritsuko Kishimoto and Kiyoshi Goda (2006) Heterologous Expression of Dehydroascorbate Reductase from Rice and Its Application to Determination of Dehydroascorbate Concentrations. J Nutr Sci Vitaminol (Tokyo). 2006 Apr;52(2):89-95.
25. Akio Nakashima, Takahiro Hasegawa, Saori Mori, Masaru Ueno, Shigeyasu Tanaka, Takashi Ushimaru, Shusei Sato, and Masahiro Uritani (2006) A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexual development in Schizosaccharomyces pombe. Curr Genet. Jun;49(6):403-413
26. Kazunori Tomita, Tatsuya Kibe, Ho-Young Kang, Yeon-Soo Seo, Masahiro Uritani, Takashi Ushimaru, and Masaru Ueno (2004) Fission Yeast Dna2 Is Required for Generation of the Telomeric Single-Strand Overhang. Mol Cell Biol. 2004 Nov; 24(21):9557-9567
27. Kazunori Tomita, Masahiro Uritani, Takashi Ushimaru, Koichi Yoshinaga and Masaru Ueno (2004) Sequence-specific binding of the Schizosaccharomyces pombe His1 protein to fission yeast telomeric DNA. Chemistry & Biodiversity Sept; 1(9): 1344-1353.
28. Masaru Ueno, Tadashi Murase, Tatsuya Kibe, Noriyuki Ohashi, Kazunori Tomita, Yota Murakami, Masahiro Uritani, Takashi Ushimaru, Masahiko Harata (2004) Fission yeast Arp6 is required for telomere silenging but functions independently of Swi6. Nucleic Acids Res. 32(2): 736-741.
29. Kazunori Tomita, Akira Matsuura, Thomas Caspari, Antony M. Carr, Yufuko Akamatsu, Hiroshi Iwasaki, Ken-ichi Mizuno, Kunihiro Ohta, Masahiro Uritani, Takashi Ushimaru, Koichi Yoshinaga, and Masaru Ueno (2003) Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand break, but not telomeres. Mol Cell Biol. 23 (15), 5186-5197.
30. Yuuki Ono, Kazunori Tomita, Akira Matsuura, Takuro Nakagawa, Hisao Masukata, Masahiro Uritani, Takashi Ushimaru, and Masaru Ueno (2003) A novel allele of fission yeast rad11 that causes defects in DNA repair and telomere length regulation. Nucleic Acids Res. 31(24): 7141-7149.
31. Tatsuya Kibe, Kazunori Tomita, Akira Matsuura, Daisuke Izawa, Tsutomu Kodaira, Takashi Ushimaru, Masahiro Uritani and Masaru Ueno (2003) Fission yeast Rhp51 is required for the maintenance of telomere structure in the absence of the Ku heterodimer Nucleic Acids Res. 31(17):5054-5063.
32. Takashi Ushimaru*, Takahiro Hasegawa, Toyoki Amano, Masao Katayama, Shigeyasu Tanaka, and Hideo Tsuji (2003) Chloroplasts in seeds and dark-grown seedlings of lotus. J. Plant Physiol., 160 (3), 321-324.
33. Akio Nakashima, Masaru Ueno, Takashi Ushimaru, and Masahiro Uritani (2002) Involvment of a CCAAT-binding complex in the expression of a nitrogen-starvation-specific gene, isp6+, in Schizosaccharomyces pombe. Biosci. Biotechnol. Biochem., 66 (10), 2224-2227.
34. Tomohusa Tachibana, Shiho Atsumi, Ryo Shioda, Masaru Ueno, Masahiro Uritani and Takashi Ushimaru* (2002) A novel non-conventional heat shock element regulates expression of MDJ1 encoding a DnaJ homolog in Saccharomyces cerevisiae. J. Biol. Chem., 277(25): 22140-22146
35. Akio Nakashima, Mayumi Yoshida, Kazutoshi Nakayama, Aya Kato-Furuno, Masaru Ueno, Takashi Ushimaru and Masahiro Uritani (2002) Genes for a nuclease and a protease are involved in the drastic decrease in cellular RNA amount in fission yeast cells during nitrogen starvation. J Biochem (Tokyo). 131(3): 391-398.
36. Takashi Ushimaru*, Yoshitaka Nishiyama, Hidenori Hayashi and Norio Murata (2002) No coordinated transcriptional regulation of the sod-kat antioxidative system in Synechocystis sp. PCC 6803. J Plant Physiol, 159, 805-807
37. Jose L. Crespo, Katsue Daicho, Takashi Ushimaru and Michael N. Hall (2001) The GATA-transcriptional factors GLN3 and GAT1 connect TOR to salt stress in yeast. J. Biol. Chem. 276(37): 34441-34444.
38. Miho Kawai, Akio Nakashima, Masaru Ueno, Takashi Ushimaru, Kazuhiro Aiba, Hirofumi Doi and Masahiro Uritani (2001) Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high concentrations of salts and high temperature. Curr. Genet. 39(3): 166-174
39. Masaru Ueno, Rumi Kurokawa, Hubert Renauld, Kousuke Watanabe, Takashi Ushimaru, Masahiro Uritani, Koichi Yoshinaga and Yasushi Hiraoka (2001) Shizosacchromyces pombe taf1+ is required for nitrogen starvation-induced sexual development and for entering the dormant G0 state. Curr. Genet. 38: (6) 307-313
40. Takashi Ushimaru*, Sumio Kanematsu, Masao Katayama and Hideo Tsuji (2001) Antioxidative enzymes in seedlings of Nelumbo nucifera germinated under water. Physiol. Plant 112(1):39-46
41. Satomi Kanazawa, Satoshi Sano, Tomokazu Koshiba, and Takashi Ushimaru* (2000) Changes in antioxidative enzymes in cucumber cotyledons during natural senescence: comparison with those during dark-induced senescence. Physiol. Plant. 109 (2) : 211-216.
42. Hiroko Oidaira, Satoshi Sano, Tomokazu Koshiba and Takashi Ushimaru* (2000) Enhancement of antioxidative enzyme activities in chilled rice seedlings. J. Plant Physiol. 156: 811-813.
43. Jun’ichi Urano, Tomofumi Nakagawa, Yasushi Maki, Takehiro Masumura, Kunisuke Tanaka, Norio Murata and Takashi Ushimaru* (2000) Molecular cloning and characterization of a rice dehydroascorbate reductase. FEBS Lett. 466(1):107-111
44. Takashi Ushimaru*, Sumio Kanematsu, Mineo Shibasaka and Hideo Tsuji (1999) Effect of hypoxia on the antioxidative enzymes in aerobically grown rice (Oryza sativa) seedlings. Physiol. Plant. 107: 181-187.
45. Junichi Mano, Takashi Ushimaru and Kozi Asada (1997) Ascorbate in thylakoid lumen as an endogenous electron donor to photosystem II: protection of thylakoids from photoinhitibion and regeneration of ascorbate in stroma by dehydroascorbate reductase. Photosynth. Res. 53: 197-204.
46. Takashi Ushimaru*, Yasushi Maki, Satoshi Sano, Tomokazu Koshiba, Kozi Asada and Hideo Tsuji (1997) Induction of enzymes involved in ascorbate-dependent antioxidative system, namely, ascorbate peroxidase, monodehydroascorbate reductase and dehydroascorbate reductase, after exposure of rice (Oryza sativa) seedlings germinated under water to air. Plant Cell Physiol. 38: 541-549
47. Yoshihiro Kato, Jun’ichi Urano, Yasushi Maki and Takashi Ushimaru* (1997) Purification and Characterization of Dehydroascorbate Reductase from Rice. Plant Cell Physiol. 38: 173-178
48. Takashi Ushimaru*, Kenichi Ogawa, Norihiro Ishida, Mineo Shibasaka, Sumio Kanematsu, Kozi Asada, Hideo Tsuji (1995) Changes in organelle superoxide dismutase isozymes during air adaptation of submerged rice seedlings: Differential behavier of isozymes in plastids and mitochondria. Planta 196(3): 606-613.
49. Shigeto Morita, Masao Tasaka, Hisao Fujisawa, Takashi Ushimaru, Hideo Tsuji (1994) A cDNA clone encoding a rice catalase isozyme. Plant Physiol. 105(3): 1015-1016.
50. Takashi Ushimaru*, Mineo Shibasaka, Hideo Tsuji (1994) Resistance to oxidative injury in submerged rice seedlings after exposure to air. Plant Cell Physiol. 35(2): 211-218
51. Takashi Ushimaru, Mineo Shibasaka, Hideo Tsuji (1992) Development of the O2–detoxification system during adaptation to air of submerged rice seedlings. Plant Cell Physiol. 33(8): 1065-1071
52. Takashi Ushimaru, Mineo Shibasaka, Hideo Tsuji (1992) Changes in levels of heme a, protoheme and protochlorophyll(ide) in submerged rice seedlings after exposure to air. Plant Cell Physiol. 33 (6): 771-778

《総説》
1. 谷内江 望、吉田知史、大西雅之、丑丸敬史、守屋央朗 (2012) 酵母コロキアム – 21世紀酵母生物学のオンラインフォーラム。細胞工学 31 (5) 604-607. (2012.04.22)
2. Katsumi Amako, Takashi Ushimaru* (2009) Dehydroascorbate reductase and salt stress. CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources. March, 2009, 4(13), 1-7.
3. 丑丸敬史*、牧野仁志穂、山田ちひろ(2008)TORによる栄養源に応答したリボソーム合成制御。化学と生物 46(6), 386-391.
4. 丑丸敬史*、塩田良(2007)栄養源に応答したTORキナーゼによるリボソーム合成制御。蛋白質核酸酵素 52(4), 342-347.
5. 丑丸敬史*、丸山裕徳、塩田良(2006)栄養源に応答したTOR/Nogsomeによるリボソーム合成制御 細胞工学:25(11), 1292-1293.
6. 増沢武弘、木嵜暁子、丑丸敬史(2006)富士山の冬を常緑で過ごす草本植物。科学 76(2), 198-201.
7. 丑丸敬史*、辻英夫 (1996) 高等植物は酸素に対してどのように適応しているか:SODなど活性酸素消去系酵素や抗酸化物質の変動を探る。化学と生物 34: 76-78.

《著書・訳書》
1. 丑丸敬史、他(2016/3/28)『<生きる>を考える』2015年度静岡大学・読売新聞連続市民講座、静岡大学イノベーション社会連携推進機構(編)、分担:「老いを科学する」(pp31-54)
2. 丑丸敬史、他(2016/3/9)『ナノバイオ・テクノロジー』静岡大学ナノバイオ科学研究分野編、静岡学術出版、分担:「細胞老化に対するナノバイオからのアプローチ」(pp88-105)
3. 丑丸敬史、泰中啓一 (2013)『酵母 —生命研究のスーパースター』静岡学術出版、分担(pp10-185)
4. 驚異の長寿因子ラパマイシン(原題“A New Path to Longevity”, David Stipp著)(2012) 日経サイエンス2012年4月号pp49-57 訳監修
5. Katsumi Amako and Takashi Ushimaru* (2011) Salt stress and transgenic plants overexpressing dehydroascorbate reductase. In “Antioixidants: Oxidative Stress Management in Plants”, ISBN: 978-93-80012-38-4, Pages: 369, Ed. Parvaiz Ahmad and Shahid Umar, Studium Press (India) Pvt. Ltd., New Delhi. pp. 55-69. (BOOK CHAPTER).