新しい有機化学反応の開発と有用生理活性物質合成への応用

(a) C2軸不斉化合物を用いた新しい分子制御法の開発
(b) 天然資源（糖、アミノ酸など）由来のカイロンを利用した新しい立体識別法の開発
(c) 高次連続不斉化合物の短段階合成
(d) 高度酸化化合物の還元反応を経由する高効率的官能基化
(e) ランタノイド化合物を用いた不斉有機反応の開発

最近研究室で合成したスピロ環状化合物

 

最近研究室で開発された新規な反応

2017年

Use of β-Amido Allylboronate as a Nucleophilic Reagent in Catalytic Enantioselective Addition to Isatins
 
European Journal of Organic Chemistry, 2017, 1285-1288.

2015年

Indium-catalyzed Amide Allylation of N-carbonyl Imides: Formation of Azaspiro-γ-lactones via Ring Opening-reclosure

Organic Letters 2015, 17, 5846-5849.

Synthesis of New Chiral Lactam–fused Pyridine Derivatives

RSC Advances 2015, 5, 73562-73565.

2014年

Catalytic Amide Allylation of Alpha-ketoester: Extremely High Enantioselective Synthesis of ester functionalised Alpha-methylene-gamma-butyrolactones

Organic & Biomolecular Chemistry, 2014, 12, 7686-7689.

2013年

Construction of Spiro-Fused 2-Oxindole/ α-Methylene-γ-Butyrolactone Systems with Extremely High Enantioselectivity via Indium-Catalyzed Amide Allylation of N-Methyl Isatin

Organic Letters, 2013, 15, 6182-6185.

Synthetic approach toward α-aminomethyl-γ-butyrolactones from β-lactam synthons elaborated by SmI₂-mediated reductive coupling reactions.

Natural Product Communications 2013, 8, 889-896.

2012年

A Synthetic Approach to Diverse 3-Acyltetramic Acids via O– to C-Acyl Rearrangement and Application to the Total Synthesis of Penicillenol Series

The Journal of Organic Chemistry, 2012, 77, 4391-4401.

2011年

New Synthetic Methodology toward Macrolides/Macrolactams via Palladium-Catalyzed Carbon-Heteroatom Bond-Forming Reactions

Synlett, 2011, 1766-1768.

2010年

Synthesis of b-Amino-functionalized a-exo-Methylene–g-butyrolactones via a b-Lactam Synthon Strategy

Synthesis 2010, 42, 3282-3288.

2009年

Extremely High Regio- and Stereoselective C-C Bond Formation of Substituted γ-hydroxylactams: Synthesis of Macronecines Based on Their Structural Duality

Tetrahedron, 2009, 65, 2415-2423.

2006年

Novel Chemoselective Desulfurization of γ-Phenylthio-substituted Aromatic Lactams: Application to the Synthesis of Isoindolobenzazepine Alkaloid, Lennoxamine

Synlett, 2006, 3407-3410.

SmI₂-promoted Novel Tandem Elimination and Coupling Reactions of Aliphatic Imides with Carbonyl Compounds; Application to the Synthesis of dl-Isoretronecanol

Tetrahedron Letters, 2006, 47, 1607-1611.

2000～2006年