人工化学酵素(Chemzyme)反応の開発

(a) chemzymatic strategy(化学酵素法)による新しい不斉点構築法の開発
(b) 金属錯体を利用し、酵素モデルを目指した触媒的立体化学制御

最近研究室で開発された有用金属錯体、酵素モデルと反応

2014年

Catalytic Enantioselective Amide Allylation of Isatins and Its Application to the Synthesis of 2–Oxindole Derivatives Spiro–Fused to α-Methylene-γ-Butyrolactone Functionality

 
Chemistry – A European Journal 2014, 20, 11091-11100.

2013年

Construction of Spiro-Fused 2-Oxindole/ α-Methylene-γ-Butyrolactone Systems with Extremely High Enantioselectivity via Indium-Catalyzed Amide Allylation of N-Methyl Isatin

Organic Letters, 2013, 15, 6182-6185.

2010年

Indium-catalyzed Enantioselective Allylation of Aldehydes with β-Carbonyl Allylstannanes: an Efficient Synthetic Method for Chiral α-Methylene-γ-lactones


Journal of Organometallic Chemistry, 2010, 695, 128-136.

2008年

Catalytic Enantioselective Allylation of Aldehydes Using b-Amido Functionalized Allylstannanes with Chiral In(OTf)3/i-Pr-pybox Complexes

Tetrahedron Letters, 2008, 49, 4701-4703.