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Total synthesis and structural confirmation of (±)-spirocollequins A and B
Keita Ichikawa, Toshiyasu Inuzuka, Hidemi Yoda and Tetsuya Sengoku
Tetrahedron Letters 2022, 107, 154109. (DOI: 10.1016/j.tetlet.2022.154109)

The first total synthesis of antiplasmodial isoindolinone alkaloids, spirocollequins A and B, has been accomplished. The proposed structures of spirocollequins have been supported through the comparison of spectroscopic properties of the synthetic samples with those of natural products as well as single-crystal X-ray diffraction analysis using a synthetic precursor of spirocollequin B.

Publication (~2016)

*2008年以降の論文のタイトルは掲載論文webサイトにリンクしています。

  • Invited review for a special issue on “New aspects in natural product synthesis: methodology and strategy
    Evolution of the Total Syntheses of Batzellasides, the First Marine Piperidine Iminosugar.
    Tetsuya Sengoku, Jolanta Wierzejska, Masaki Takahashi and Hidemi Yoda, Natural Product Communications 2013, 8, 1011-1019.

  • Invited article for a special issue on “New aspects in natural product synthesis: methodology and strategy
    Synthetic approach toward α-aminomethyl-γ-butyrolactones from β-lactam synthons elaborated by SmI2-mediated reductive coupling reactions.
    Masaki Takahashi, Takahiro Sudo, Yusuke Murata, Tetsuya Sengoku and Hidemi Yoda, Natural Product Communications 2013, 8, 889-896.