Long-lasting suppression of mechanical allodynia in mice by intrathecal administration of an anti-cell adhesion molecule 1 antibody

Ichiro Takasaki, Fuka Takeuchi, Ryohei Miyamae, Yuto Mochizuki, Hayate Kinoshita, Man Hagiyama, Azusa Yoneshige, Takao Inoue, Tetsuo Narumi, Akihiko Ito*

Abstract:

Cell adhesion molecule 1 (CADM1) is a member of the immunoglobulin superfamily and is abundantly expressed on nerve fibers. Recently, the anti-CADM1 ectodomain antibody 3E1 has proven potentially useful as a local anesthetic due to its high affinity to subcutaneous nerve fibers. When injected intrathecally into mice, where 3E1 accumulates and whether it serves as an analgesic was examined.