An NVOC-based Photolabile Solubilizing Tag for the Chemical Synthesis of Poorly Soluble Peptides and Proteins

An o-nitroveratryloxycarbonyl-based solubilizing tag was developed to improve the chemical synthesis of poorly soluble peptides and proteins. Tag installation markedly enhances the aqueous solubility of hydrophobic peptide fragments while allowing clean removal via UV irradiation. This strategy facilitates efficient handling of challenging fragments and supports downstream peptide ligation for the synthesis of hydrophobic proteins.

Org. Lett., accepted.